COVID health needs of Aboriginal communities in NSW
A strengths-based, social research study into the experiences with and health needs relating to COVID in three Aboriginal communities in NSW
Development of sensitive, specific COVID-19 antibody tests
Development of rapid, sensitive, specific antibody tests to diagnose disease, trace cases in the community and assess vaccine effectiveness
Improved confirmatory diagnosis of SARS-CoV-2 infection using protein mass spectrometry
This research project aims to develop a new test to detect viral proteins in patient samples. Virus will be extracted from nasopharyngeal swabs and processed for analysis via liquid chromatography and mass spectrometry (LC-MS) to measure the viral proteins. These results can be used together with the gene tests to evaluate infection status and provide more definitive diagnosis in the case of ambiguous results from current testing methods. This methodology could be adapted for other viruses including influenza and may be used to detect emerging viral mutations
Enhanced genomic tracking of COVID-19 importations and transmissions in NSW
How can sensitive, enhanced WGS techniques enable high-resolution SARS-CoV-2 genome sequencing from low viral load samples? We intent to improve SARS-CoV-2 genome surveillance and enhance its consequent public health utility and impact in NSW
Place-based COVID response for Aboriginal communities
To develop a culturally-safe, place-based response to COVID-19 for NSW Aboriginal communities and to safeguard effective service provision by ACCOs
Impact of COVID-19 on preventive health behaviours of Aboriginal communities
Indigenous people experience high rates of chronic illness. COVID restrictions may have made seeking preventive health more challenging
45 and Up COVID Insights is an agile research program seeking to understand the impacts of COVID and deliver timely evidence to guide decision-making
Arterial Access System (AVAS®)
The Arterial Access System (AVAS®) is an implantable medical device that enables clinicians to access the arterial circulation and provides an ability to isolate and independently target a tumour within a specific organ in the body
Developing an efficient and cost-effective platform technology for regenerative medicine and bioresorbable bone implants
Therapeutic acute intermittent hypoxia
Developing a novel treatment to restore voluntary function after spinal cord injury
Neuro-cardiac self-regulation therapy
Clinical trials and translation of a novel neuro-cardiac self-regulation therapy to improve autonomic and neural function after spinal cord injury
Immersive virtual reality treatment for restoring touch perception in people with discomplete paraplegia
Early & intensive SCI-MT trial
Early and intensive motor training (or usual care) to enhance neurological recovery and function in people with recent spinal cord injury
Mechanisms underlying chronic pain following spinal cord injury
The aim of this study is to extend the current understanding of the causes of spinal cord injury pain with a focus on changes in the functioning of specialised brain cells (astrocytes) in causing the pain
Abdominal stimulation translation into worldwide clinical practice
Abdominal stimulation to improve clinical outcomes after spinal cord injury: translation into worldwide clinical practice
Metagenomics based diagnostics for urinary tract infection control
Diagnostic tool to predict and manage urinary tract infections
From cardiotoxicity to cardioprotection
Can we treat cancer without breaking the heart? From cardiotoxicity to cardioprotection – reversing the impact of cancer therapies on cardiovascular health for cancer patients
Overcoming the barrier to human cardiac gene therapy
Overcoming the major barrier for gene therapy as a treatment modality for patients with all forms of heart disease
Elucidating the genetics of spontaneous coronary artery dissection
Developing new quantitative and analytical approaches to improve identification of mutations that cause spontaneous coronary artery dissection
Scalable intervention to improve cardiovascular risks in primary school students
Assessing the impact of a simple intervention to improve physical activity and cardio-respiratory fitness among primary schools student
Radiation-ablation techniques to treat ventricular tachycardia and atrial fibrillation
Developing new techniques to make radiation-based treatment for atrial fibrillation and ventricular tachycardia safer
Standard care or a rapid early invasive management (STORM) approach to patients with life-threatening heart rhythm disorders
Establishing a centre for pre-clinical evaluation of cardiovascular devices
Developing new materials and devices to better treat cardiovascular disease, including grafts, stents and valves
Treatments to restore blood pressure in septic patients
Defining new treatment options for the restoration of normal blood pressure in experimental sepsis
Investigating novel therapies for heart failure with preserved ejection fraction
Finding a new treatment for these patients, which will help them feel better, lose weight and reduce hospitalisations
Impact of obesity on cardiovascular hemodynamics
A life span study of the impact of obesity on cardiovascular hemodynamics
Targets for the prevention of cardiovascular thrombosis in metabolic syndrome
Using new technology to measure effects of thiol enzymes, coupled with disturbed flow, and evaluation of a new blood test to detect sticky blood
Improving new cardiac procedures with advanced computer simulation
Using computer simulation to practice heart surgery using different valve sizes, positions and techniques
Interactive peer support based on the concept of emotional contagion for secondary prevention of cardiovascular disease
The role of hypoxia inducible factor in the development of heart failure
Combating deadly sticky blood clots in diabetes
Lifestyle strategies that target post meal glucose spikes
To investigate the impact of two lifestyle therapies that target the lowering post meal glucose spikes on blood vessel health
Redox control of VWF processing and activity during thrombotic diseases
Identifying novel proteins which can be targeted to stop blood clots from starting to develop
Microwave ablation system for treating hypertension
Targeting Tet2 as a therapy for vascular calcification
Identifying new genes that cause vascular calcification for earlier initiation of life-saving therapies
Preventing obesity in adolescents using interactive text message program
Generating evidence on text message programs to improve BMI, diet, physical activity and mental wellbeing in adolescents
Targeting blood vessel cells to treat atherosclerosis
Generating new understanding of the initiation and progression of atherosclerosis
Build a nationally leading and internationally recognised program of research that improves outcomes for women with heart disease
Assessing diabetes mellitus platelet hyperactivity to provide insight into the mechanisms by which they contribute to unresolved inflammation
Systematically understanding phosphatase and actin regulator 1 (PHACTR1)
Therapeutic targets to inhibit SNS activation
Therapeutic targets to inhibit sympathetic nervous system activation
Developing safer anticoagulants for the treatment of stroke
Towards the development of safer drugs that can improve the clot-busting potential of rtPA
Preeclampsia as a major independent risk factor for cardiovascular disease
What is it about preeclampsia that makes for cardiovascular risk, and is it preventable?
Clotting mechanism causes and new and safer drug discovery
Elucidation of clotting mechanisms that cause cardiovascular disease and discovery of new more effective and safer drugs to prevent and treat
Broadening the use of sodium glucose 2 transporter
Design, fund and implement new, large-scale international collaborative trials of SGLT2 inhibitors amongst patients with diabetes
Role of the intrinsic cardiac nervous system in myocardial ischaemia
Understanding the role of the intrinsic cardiac nervous system in myocardial ischaemia (decreased blood flow and oxygen to the heart muscle) and arrhythmias
Improving health outcomes in congenital heart disease
Developing the best picture yet, internationally, of the burden of disease on young adults with congenital heart problems, across the life course
Modifiers in familial dilated cardiomyopathy
Identification of disease modifiers in familial dilated cardiomyopathy Incorporation of risk factor management as an important component of personally-tailored clinical care for TTNtv-related dilate cardiomyopathy
Preventing and reversing accelerated atherosclerosis in patients with diabetes
Evaluate the capacity of a new peptide called C-II-a that mimics the cardioprotective properties of the main HDL apolipoprotein to reduce heart disease in people with diabetes
Preserving brain blood flow during stroke by preventing intracranial pressure elevation
Myocardial ischaemia reperfusion injury – applying the acid test
Testing the effectiveness of combining Hi1a and empagliflozin in experimental models of heart attack and of heart transplantation
Redefining protein function in thrombosis
Implications for pro-thrombotic states and anti-thrombotic drug resistance in patients with cardiovascular disease
New prothrombotic mechanism linking diabetes to cardiovascular disease
Understanding why these patients are at greater risk of developing blood clots and dying from cardiovascular disease
Enabling precision medicine by “deep phenotyping” cardiovascular disease with imaging
Colchicine cardiovascular outcomes in acute coronary syndrome study - imaging/biomarker substudy
Waratah Vaccine Trial Alliance
A multidisciplinary collaboration of leading and emerging clinical vaccine trial researchers, consumers and other stakeholders
An initiative to improve NSW capacity and capability to conduct adaptive clinical trials for the treatment of COVID-19
COVID-19 in educational settings investigation
Examining the extent to which SARS-CoV-2 is transmitted within school and early childhood education and care settings in NSW
Serosurveillance for SARS-CoV-2 infection
Understanding the extent of community SARS-CoV-2 antibody prevalence by age group, sex and population in NSW.
COVID-19 First Few Hundred (FFX) study
Understanding secondary infection rate for household contacts and factors associated with variation in secondary infection risk
A research platform that can support a diverse range of research initiatives to better understand sleep health and its link to chronic diseases.
Serum biobanks for infectious diseases studies
A series of population, age and location matched serum biobanks.