Development of a variant-proof COVID19 mRNA vaccine
This project aims to develop a next generation vaccine able to prevent infection from all future variants of SARS-CoV-2, the virus that causes COVID19
Smart Nanogel for Intranasal Brain Delivery of RNA
Development of a temperature-responsive nanogel nasal formulation to deliver RNA to the brain for the treatment of Alzheimer’s Disease.
Reducing the risk of blood thinners in heart disease
Development of a new diagnostic device with RNA technology that will reduce risks of blood clotting and bleeding complications.
TLR2/6 agonist-boosting immunogenecity of tumour-targeting RNAi-based nanomedicines
The team will determine the therapeutic potential of a drug based on incorporating an immune stimulating molecule within a nanomedicine that uses RNA to increase anti-tumour activity
Smartphone Aptasensor Breathalyser for Detection of Infectious Diseases
The development of a portable aptasensor breathalyser for the detection of infectious diseases.
siRNA gene therapy for rectal cancer
Exploring the anti-tumour efficacy of gene therapy via liposome-siRNA formulation for rectal cancer.
Cellular production of targeted RNA therapies
A cellular system for the manufacture of exosome-based targeted RNA therapies to treat cystic fibrosis.
Developing a new therapeutic for childhood cancer
Development of circular RNA sponges with anti-tumour effect in the childhood cancer neuroblastoma.
Using CRISPR to prevent diet-induced obesity
Using the latest advances in RNA technology to develop targeted drugs to fight obesity.
Now you see me: Preserving vision through RNA
This research will identify serum-derived RNA molecules that diagnose early-stage retinal degeneration and develop biosensors for their detection.
Tobacco smoking is a leading cause of death and illness. This project implements and evaluates a program to support smokers in hospital to stop.
This project will determine the feasibility and acceptability of a cultural mentoring program designed for Aboriginal and Torres Strait Islander nurses and midwives across five diverse local health districts (LHDs).
Asthma Care from Home: Evaluating impact, implementation and cost-effectiveness of comprehensive asthma care closer to home for rural children.
This research will inform the future direction of virtual care service delivery for people with intellectual disability and their families.
Tharawal Holistic Indigenist Specialist Interdisciplinary Metabolic Clinic: A replicability and adaptability study to improve metabolic health in Aboriginal clients of an Aboriginal Medical Service (AMS).
SUSTAIN - Sustaining Strengthening Care for Children
SUSTAIN: Strengthening paediatric primary care, using an online integrated GP-paediatric care model to deliver equitable, quality care for children close to home and reduce unnecessary referrals.
The REDUCE Trial: Restoring microvascular circulation with diagnostic ultrasound and contrast agent
Novel additional treatment for heart attacks to salvage heart muscle with ultrasound and contrast agent (REDUCE project).
To compare the effectiveness, cost and environmental impact of using two rather than three prophylactic methods to prevent blood clots after surgery.
Implementing a Primary-Tertiary Shared Care Model for Scaling Up Genetic Medicine
Implementing a general practice and medical specialist shared-care model for genetic medicine to improve familial hypercholesterolemia (FH) detection
This research aims to generate new knowledge to inform how school-based nutrition programs can be successfully scaled-up. A randomised controlled trial will evaluate the NSW scale-up of a text-message based healthy lunchbox program ‘SWAP-IT’ to improve child nutrition.
Testing a nurse-led therapeutic intervention to reduce aggression and restrictive practice in acute mental health facilities.
A trial to test whether a non-traditional health care environment in NSW (Hairdressing Salons) can be used to improve heart health in women by effectively encouraging them to have a heart health check with their general practitioners.
Towards high accuracy cardiovascular risk prediction
This project will develop the first precision-based risk assessment tool to accurately identify individuals who are at risk of an adverse cardiovascular event. Using latest machine learning techniques and computation methods, the project will use a large retrospective data set with linked patient outcome data to develop and validate a unique tool which can be integrated into standard clinical practice via cloud-based computing software. Using the patient’s medical images, and other available health data, it will outperform current risk assessment methods. These current methods are based only on a few generic indicators and ignore potential patient-specific markers embedded within the available information. Specifically, by using latest computation methods, for the first time, we will be able to compare individual variation within the population. This will likely reveal the currently remaining 30% of unknown factors for cardiovascular health risk.
The main researcher for this project is Dr Susan Beier
Brain function in complex congenital heart disease
Brain injury and dysfunction in young adults with complex congenital heart disease (CHD): Defining the natural history and potentially modifiable contributors.
The main researcher for this project is Dr Rachael Cordina.
A decision-support tool for physical activity strategies
By co-designing a decision-support tool, we will guide policymakers in implementing the best strategies to promote physical activity in NSW.
Use of diabetes prevention services to reduce cardiovascular disease (CVD)
Evaluate the long-term health outcomes and cost-effectiveness of existing resources available for people with or at risk of diabetes to reduce CVD.
Colchicine nanotherapy to combat artery blocking
Developing a safe and effective nanomedicine to reduce artery narrowing and blocking
Preventing heartbreak after hypertensive pregnancy
Tracking women’s health and closing knowledge gaps of women and healthcare providers to improve heart health after high blood pressure pregnancy
Using genomics to improve care of inherited cardiac diseases
This project will develop evidence for an expanded role for cardiac genetic testing, to include clarifying diagnosis and improving management/outcomes.
Magnetic Resource Imaging (MRI) imaging in heart transplant
To develop a better and non-invasive approach to clinically manage the medication needs of heart transplant recipients.
State-of-the-art diagnostics in chest pain
Reducing unnecessary investigations in chest pain with state-of-the-art diagnostic cardiac techniques
The purpose of this study is to determine the impact of sleep apnoea management with CPAP therapy on atrial fibrillation (AF) burden.
Improving Aortic Stenosis Care with Machine Learning
Improving patient selection and timing of valve intervention in patients with aortic stenosis using computer vision and machine learning
Replenishing a vital molecule to rescue stiff heart failure
Stiff heart failure is now the most common form of heart failure. But it has no therapies. We have discovered a molecule that is depleted in the hearts of these patients. Our early work suggests that replenishing this molecule rescues this type of heart failure. Now, we would like to formally test this strategy and develop the first treatment for this disease.
Novel strategy for chronic wound healing
To develop a new wound dressing for the treatment of chronic wounds.
A Safer Intervention for Peripheral Arterial Disease
Building a new device intervention for peripheral arterial disease with improved long-term effectiveness and safety.
Reducing the risks of Artificial Hearts for patients with Heart Failure
Development of a new artificial heart implant with a Slippery Nano-Coating that will reduce blood clotting and failure of these implants.
Promoting blood vessel formation in oxygen deprived tissue
This project will identify inhibitors of a new oxygen sensing system to increase blood vessel formation in ischemic cardiovascular disease.
Novel way of gene control to treat aortic aneurysms
Identifying new ways to treat aortic aneurysms through chemical modification of aneurysm-regulated genes.
‘Medically-Tailored Meals’ to prevent heart disease
A randomised controlled trial of Medically-Tailored Meals (MTM) to prevent heart disease for patients with type 2 diabetes.
Improving genetic diagnosis of heart disease
This project will increase the diagnostic yield of genetic testing in people with inherited heart disease.
Impact of NAD deficiency on congenital heart disease
Reducing the impact of nicotinamide adenine dinucleotide (NAD) deficiency in causing congenital heart disease (CHD), extra-cardiac anomalies (ECA) and miscarriage.
Targeting the unmet needs in coronary artery disease
Targeting the unmet needs in coronary artery disease - from bedside to bench to bedside.
Improving risk management of patients with congenital cardiac myopathy
Identifying new biomarkers to predict the risk of adverse cardiac event for patients suffering from congenital cardiac myopathy.
Preventing Disabling Stroke from Atrial Fibrillation
Preventing Disabling Stroke from Unknown and Undertreated Atrial Fibrillation by ECG Screening in General Practice, Engaging Patients, and Increasing Treatment Persistence.
Spontaneous coronary artery dissection (SCAD): disease mechanisms and complications
To understand the genetic and cellular mechanisms, and psychosocial burden of SCAD - Spontaneous coronary artery dissection, a life-threatening disorder that predominantly affects women.
Tailored Gene Therapeutic Strategies for Peripheral Vascular Disease (PVD)
Tailored Gene Therapeutic Strategies for Peripheral Vascular Disease (PVD).
Piezo1 mechanoreceptors in heart health and disease
Establishing the role of the Piezo1 mechanotransducer ion channel in pressure-overload induced left ventricular hypertrophy (LVH) using a mouse model.
Peer support for people with heart disease in NSW
Implementation and evaluation of a peer support program for people with heart disease: Harnessing technology and lived experience of survivors.
How do drugs bind to cardiac potassium channels?
To determine how drugs bind to hERG channels and then develop a computer program to predict drug modifications to reduce affinity for hERG channels.