A standardised pathway for the management of platelet-related bleeding in NSW
Reducing abnormal bleeding symptoms throughvia the use of a specialised service incorporating both state-of-the-art laboratory testing and treatment planning.
Addressing food security for Aboriginal families through school and community support
A hybrid implementation trial of a co-designed school and community approach to improve food security for Aboriginal families.
Advancing novel gene therapy for dementia
This project aims to overcome clinical barriers to a new gene therapy for dementia and motor neurone disease.
Better understanding cell interactions in heart disease
Improving outcomes for patients suffering from heart failure or heart attack by using powerful new technology to analyse unique human biospecimens.
Blood ‘fingerprinting’ to detect and monitor glioblastoma
Using AI models to confirm blood ‘fingerprints’ to detect glioblastoma recurrences and predict treatment response and outcomes.
Blood and bone: multiomic study of arthritic joints
Improving patient outcomes in inflammatory arthropathies, by applying cutting-edge genomics to precious, discarded joint tissues.
CHD-GEN: Genetic and Environmental factors determining congenital heart disease recurrence
Genetic and Environmental factors determining congenital heart disease recurrence: Identifying potentially modifiable contributors.
Design and evaluation of an integrated legionellosis surveillance system for NSW
This research will improve the NSW response to outbreaks of legionellosis disease. The main researchers for this project are Professor Vitali Sintchenko (NSW Health Pathology and the University of Sydney) and Dr Eby Sim (University of Sydney).
Can improved outcomes for type 1 diabetes be achieved through the roll out of a paediatric diabetes management program?
Development of a nanomedicine for pancreatic cancer
The research will use cutting edge nanomedicine technology to develop a more effective treatment for pancreatic cancer.
Trialing digital psychosocial screening of youth in Emergency Departments using the eHEEADSSS.
Implementation of a toolkit to improve blood pressure management by providing tailored support from community Pharmacists.
Virtual care is becoming increasingly important for the delivery of high-quality care in the community. Virtual Care Pathways (VCPs) are being developed, with an increase during the COVID-19 pandemic, to sustainably improve access to health care by reducing unnecessary travel and wait times to receive specialist support. Consumers and clinicians have sought to maintain virtual care as a sustainable and readily scalable option for healthcare beyond the pandemic however there is some concern about the loss of social interaction, lack of physical examination and low digital literacy. Maintaining opportunities for face-to-face interactions while enhancing access to specialist support on country is particularly important to Aboriginal patients living in remote communities.
Evaluation of a new drug to prevent and treat heart disease
Looking for evidence that the innovative, dual-acting drug, SSAOi/MPOi, prevents heart disease and reduces tissue damage after a heart attack.
This project aims to find new ways to protect the heart from progressive deterioration in families with genetic disorders of the heart's contraction and rhythm.
Generating evidence to determine whether health literacy-informed interventions improve the access to and use of health services for people in New South Wales prisons.
Finding genetic clues to treat cystic kidney disease
The intent of the research is to uncover new genetic clues that can lead to precision therapies in Autosomal Dominant Polycystic Kidney Disease
To implement an evidence-based Frailty Response Program to improve the outcomes of frail adults undergoing heart valve replacement procedures.
Identifying genetic risk factors for spontaneous coronary artery dissection
This project aims to understand the role of genetics in spontaneous coronary artery dissection to improve risk prediction and ultimately treatment.
This project aims to improve outcomes for patients who suffer a prolonged cardiac arrest by implementing ECMO at the scene of cardiac arrest.
Improving treatment selection for patients with leukaemia
The research will test a new approach to individually match leukaemia patients to their optimal therapy
Investigating how bacterial viruses can treat infections
Investigating how measurements of phage levels in the blood of patients receiving phage therapy can inform how effective the treatment is.
Kids Connect Integrated Hybrid program
The Kids Connect Integrated Hybrid program aims to engage and empower parents, including from priority groups, to access developmental checks and support early.
LOTUS Trial: LOw dose anti-hypertensive combinations To improve stroke oUtcomeS
The LOTUS trial will focus on patients who have had a previous ischaemic stroke or mini-stroke. It will test whether a new model of stroke care will achieve better blood pressure in patients compared to patients who receive the usual therapies.
Nanovesicle gene therapy for polycystic kidney disease
Development of a nanovesicle gene therapy for the manufacture of a drug targeting polycystic kidney disease
Overcoming antibody barriers to adeno-associated virus for gene therapy
The intent of the research is to “cloak” adeno-associated virus vectors to evade antibody neutralisation and provide broader patient access to transformative gene therapies.
REducing cardioVascular and kidnEy RiSk in people with diabEtes (the REVERSE study)
The impact of a cardiovascular nurse coordinator on improving the health outcomes of people with diabetes at high-risk of heart and/or kidney disease.
This resistance exercise program aims to make people with heart failure feel stronger, improve their physical function, and keep them out of hospital.
This study will work out how to get people with hypertension to switch from using regular salt to using potassium-enriched salt, which helps to reduce blood pressure.
Targeting vulnerabilities in the tumour and immune ecosystem to treat cancers
This project aims to analyse the tumour microenvironment. It will target vulnerabilities in the immune ecosystem of cancer with the goal to find new therapeutic trials to deliver cures.
Helping us age better through maintaining the health of our blood vessels, understanding the ageing process and developing novel therapeutics.
Thickening the cap: a novel NOTCH3 mediated RNA therapy for atherosclerosis
Using nanotechnology to prevent fatty plaques in blood vessels from rupturing and stopping blood flow.
Using Artificial Intelligence (AI) to support better decision-making in acute stroke
Providing enhanced treatment recommendations and outcomes prediction for patients with acute stroke through the use of AI and external validation using real-world data in NSW.
The intent of this research is to develop new methods to make functional cardiac tissue and injectable biomaterials for the treatment of heart attack.
Virtual Partnered Pharmacist Medication Charting (VPPMC) to improve medication safety.
Delays and errors in charting patients’ medications upon admission to hospitals lead to longer length of stay. The current process of identifying medication errors retrospectively is time-consuming, delays the accurate charting of medications, and may lead to hospital-acquired complications (HACs) for patients. A model called Virtual Partnered Pharmacist Medication Charting (VPPMC) will empower hospital pharmacists to chart patients medications, in consultation with doctors on admission to rural and remote hospitals to prevent medication errors.