Development of Novel Tests to evaluate duration of immunity after COVID-19 and in vaccine trials
Ultra-sensitive PC2 serology and rapid viral outgrowth assays
The project aims to improve SARS-COV-2 antibody and virus diagnostic detection in the time of COVID-19
24/7 eICU model of care for Level 4 ICUs in rural NSW
Implement and study virtual care enhanced management of patients in Level 4 rural and regional ICUs using NSW Health value-based care model
Develop and scale up a digital tool to help NSW bend the predicted curve in depression, anxiety, and alcohol use due to COVID-19
Digital solution to address the mental health and psychosocial impacts of the pandemic for children and their parents in the first 2000 days
Supporting the mental health of health workers at Aboriginal Community Controlled Health Services in New South Wales during COVID-19 and beyond
Designing and testing COVID-19 vaccine public health messages
This research seeks to understand NSW community perspectives on COVID-19 vaccines and develop evidence-based public health messages for COVID-19 vaccine communications
Therapeutic cell bank of virus-specific immune cells targeting COVID-19
We will create a cell bank of coronavirus specific immune cells that will be available for clinical trial use if the rate of community transmission rises in the future
Rapid Evaluation of a Scalable Program for Reducing Common Mental Disorders During COVID-19
This project evaluates a video-conferencing program led by clinicians and supported by an app program to reduce mental disorders during COVID-19
Evaluation of the Virtual Rural Generalist Services (VRGS) as an effective, “COVID-19 resilient” model of care
Long-acting depot buprenorphine impact for opioid dependence
How does long-acting depot buprenorphine impact on the high-risk post-release period for people with opioid dependence?
A holistic first 2000 days model of care for migrant and refugee populations
Web-based shared care plan and telehealth solution for patients with severe mental illness
Enhancing integration with primary care of patients with severe mental illness using a web-based shared care plan and telehealth solution
The m-PRTM Implementation Project
Mobile Health Technology Solutions to Expand Pulmonary Rehabilitation Services for Chronic Obstructive Pulmonary Disease
Efficacy and Value In ExpeDited out of hospital arrEst care ANd ECMO CPR (ECPR)
Delivering equitable care to children in rural NSW
Phage therapy for extremely drug resistant Shigella
Development of phage combinations that kill the agent of bacterial dysentery (Shigella) ‘hiding’ inside cells and restore the power of antibiotics
Preventing therapeutic failure during phage therapy
Preventing clinical failure in phage therapy by recognising and re-engineering pseudolysogenic phages
Phage therapy for non-typhoidal Salmonella infection
Development of combinations of bacteriophages (bacteria-eaters) that effectively kill non-typhoidal Salmonella, one of the main causes of gastroenteritis outbreaks in Australia
Using phages to target antibiotic delivery
We will use phages to deliver high doses of antibiotics to site, improving their efficacy and reducing their toxicity
Phage therapy for intracellular pathogens
Development of phage – antibiotic combinations that effectively kill diarrhoeal pathogens (e.g., Shigella, Salmonella) inside mammalian cells
Phage therapy for rapidly growing mycobacteria
This project will define and refine therapeutic bacteriophages to treat drug resistant mycobacteria that cause severe disease in the lungs, skin and soft tissue of children and adults
Viral vectors for gene therapy applications targeting the central nervous system.
Development of next-generation liver-detargeted AAV vectors for gene therapy applications in the central-nervous system
Nucleic Acid Therapeutics for Preventing Preterm Birth
To use targeted nanoparticles to safely deliver nucleic acid therapeutics to the pregnant human uterus to prevent preterm birth
Safer and more effective transplants
Cellular therapy interventions to improve outcomes in haematological malignancies
Bioengineering of next-generation adeno-associated viral vectors
Adeno-associated viral vectors for clinical applications using a whole human liver explant preclinical model
The purpose of this study is to obtain pilot data for a multicentre randomised trial evaluating the impact of CPAP therapy on atrial fibrillation (AF) burden
Medication persistence tools for atrial fibrillation
Digital tools for general practitioners and patients to improve long-term taking of stroke prevention medications in people with atrial fibrillation (AF)