Testing new treatments for schizophrenia
This project aims to find out if targeting the glutamate system can reverse dopamine dysregulation in the inflamed brain.
Brain immune cells as treatment targets for schizophrenia
The intent of this study is to determine if microglia can be targeted by interventions to improve or prevent all symptoms of schizophrenia
Precision medicine for schizophrenia
We will demonstrate a genetically informed precision medicine approach for schizophrenia treatment using patient derived cerebral tissue culture
Mechanisms of vascular thrombosis
This project aims to improve outcomes in catastrophic clotting syndromes that are driven by the immune system: heparin induced thrombocytopenia and anti-phospholipid syndrome.
Optimising blood pressure control in Australia
This project will harness NSW leadership to drive a multifaceted approach in translation research and aims to increase blood pressure control rates from 32% to 70% by 2030.
Enhancing heart repair to treat cardiomyopathies
This project aims to develop innovative treatment to repair damaged heart muscle to improve outcomes, wellbeing and survival after heart attack and other cardiomyopathies.
Engineering next generation aortic valve replacement materials
This project aims to develop a new generation of heart valve materials for the treatment of aortic heart valve disease.
Defining atrial muscle dysfunction for identifying patients with atrial cardiomyopathy
This Project aims to Identify patients at risk of developing an irregular heart rhythm (atrial fibrillation) by identifying early changes to predict atrial dysfunction. Additionally, the aim is to find new therapies to treat the underlying cardiomyopathy rather than waiting for them to develop atrial fibrillation.
Detection of Atrial Myopathy to prevent recurrent Embolic Stroke
This project aims to assess Atrial Myopathy in stroke patients, so that all patients will get the most effective prevention of recurrent stroke.
Enhancing Biocompatibility of Cardiovascular Devices
This project aims to develop a universal and scalable platform technology to reduce calcification and blood clots in blood-contacting devices.
Developing new anti-clotting therapy for stroke
Development and pre-clinical evaluation of novel anti-clotting therapies for the treatment of acute ischemic stroke.
In utero saccharide exposure: Revisiting the provenance of hypertrophic cardiomyopathy
Eating excessive added sugar during pregnancy mediates adverse effects of foetal cardiac development which persists into adulthood. This research looks at the effect of maternal diet on offspring long-term health.
Establishing a genomic platform for timely identification and characterisation of childhood infectious diseases causing severe illness and death.
Gut-brain interactions in young people with cancer
We aim to improve understanding of how chemotherapy affects the brain by studying gut microbes in young people with cancer.
Faecal microbiota transplantation (FMT) in immunotherapy associated colitis
A randomised controlled trial assessing use of oral FMT in the management of immunotherapy associated colitis.
Using metagenomic shotgun sequencing and metatranscriptomics to deeply phenotype the mucosal microbiota of patients undergoing colorectal resection with the aim to identify microbial factors which affect surgical outcomes, such as healing and anastomotic leaks.
Multi-omics enables accurate Faecal microbiota transplantation (FMT) donor selection
Characterise multi-omics features of obesity and dementia against healthy microbiome and develop an innovative approach of donor selection for FMT.
Targeting the microbiome to improve cancer outcomes
This project seeks to translate knowledge of the gut microbiome into improved cancer immunotherapy treatment outcomes.
Zoonotic viruses of New South Wales
Characterising viruses from bats and mosquitoes in NSW that are pathogenic to humans as an early warning system.
Creating safer blood thinners to save stroke patients’ lives
Creating new blood thinners with lower bleeding risks that successfully bust stroke causing blood clots, ultimately saving lives.
Endogenous plant symbionts known as endophytes, will be characterised for their ability to transcriptionally respond to stressor challenges.