Stroke is a leading cause of death and disability in Australia. The provision of this grant will establish an Australia-first NSW-wide brain clot bank that would allow improved diagnostic pathways and opportunities for research in stroke patients. Brain clots retrieved after mechanical procedures will be collected as part of the clot bank. The emergence of endovascular thrombectomy (EVT) has significantly improved standards of care and outcomes in ischemic stroke patients and opened doors to critically examine brain clots retrieved after the procedure.