The Sydney Catalyst ‘Embedding Research (and Evidence) in Cancer Healthcare – EnRICH’ program is a prospective clinical cohort of 1000 patients with lung cancer, which aims to better define, treat and care for patients in Sydney Catalyst member hospitals, and to provide infrastructure for translational cancer research. The program is capturing diagnostic tumour specimens and serial blood samples for molecular and biomarker studies, with matched demographic, clinical and outcome data (including patient reported outcomes) to answer defined program core research questions, and support further translational research in lung cancer in NSW through linked sub-studies.