This project will create a unique, open-access platform for research to improve brain cancer patient survival
What is the issue for NSW?
Glioblastomas are universally fatal brain tumours, with common occurrence in young adults. Currently treatment options are limited with surgical resection still being gold standard followed by standard chemo radiation. Tumours re-emerge aggressively following treatment and usually develop treatment resistance. Depending on the location of the tumour within the brain, this can be often challenging with a significant risk of mental and physical impairment . Tumour recurrences often result in premature death with lack of targetable agents available for treatment.
What does the research aim to do and how?
This study aims to create a unique, open-access platform for critical research to improve brain cancer patient survival. Recent molecular profiling has shown that Glioblastomas and diffuse gliomas are quite diverse group of tumours and based on their molecular signature, clinical behaviour and treatment response can vary. Further work is required to identify targetable mutations and personalised treatment. This will be achieved through expanding collections from glioma patients, at an additional site, ICPMR Westmead.